Get Accurate Results From Our Gas Chromatograph and Liquid Chromatograph Mass Spectrometer Systems

The AB Sciex 4500 LC/MS/MS is the intelligently re-engineered design of the 4000 QTRAP Platform and sets a new benchmark for robust quantitation and library searching. The system is ideal for laboratories requiring ultimate robustness, ruggedness, and reliability for high-throughput screening of many compounds in many samples every day.

The AB SCIEX 4500 has been re-engineered to set a new benchmark for reliable quantitation and library searching - with 100 fold more full-scan sensitivity over basic triple quadrupoles in the same class. The LC/MS/MS covers key performance criteria: Quantitative sensitivity, dynamic range, scan speed, ionization source flow range, and footprint.

Features:

• TurboV ionization source- The gold standard for LC-MS/MS ionization, the TurboV ionization source was made for demanding applications, with a patented design that delivers highly efficient desolvation for stable, sensitive performance across a wide range of flow rates from 50 uL/min up to 3 mL/min, with the versatility of ESI and APCI ionization capabilities and compatibility with microflow hybrid electrodes (to extend flow regime down to 5 uL/min) in the same source so you can run a wider scope of methods on your system.
• Curtain gas interface- The curtain gas interface provides a wall of clean nitrogen to help prevent neutral components from entering the mass spec, so the system is more robust, requires less maintenance, and delivers increased uptime for your lab. When tested against 1500 plasma injections, the combination of interface and source delivered consistent quantitative results with response CVs & lt; 4%.
• QJet ion guide- The QJet design is what brings the system reliability and sensitivity, providing increased uptime, reduced maintenance, and improved ion transmission efficiency which enhances overall sensitivity.
• LINAC collision cell- The engineering of patented Qurved LINAC collision cell provides fast and efficient ion fragmentation, with insignificant crosstalk, so you are able to get higher quality MRM and MS/MS data, particularly for high-throughput methods with hundreds of compounds.
• AcQuRate pulse counting detector- The AcQuRate pulse counting detector was designed for reproducibility and accuracy, providing excellent results for low level compound detection and a wide dynamic range.
• Dynamic range- Achieve up to 5 orders of dynamic range for high performance quantitation in your first injection, reducing the needs for repeat analyses for increased productivity.
• Mass range- The 5 to 2000 Da mass range allows flexibility to tackle a large scope of quantitation assays on your single mass spec system.
• Ultra-fast MRM cycle times- With 1 minimum dwell times of 1 msec for MRM acquisition, you can screen for more compounds in every pass, increasing your throughput and data quality.

Triple Quad LC-MS/MS systems deliver superior quantitative results in a single injection workflow. When you activate the optional QTRAP functionality, your instrument acts as a linear ion trap (LIT). This allows you to acquire even more data from your sample without sacrificing the sensitivity or quality of your multiple reaction monitoring (MRM) analysis. The QTRAP technology incorporates additional scan types, such as MRM3 (MS/MS/MS), Enhanced Product Ion scans (EPI) and many more. The additional scans can run at the same time you are acquiring your MRM, without any impact on performance or quality of data.

The SCIEX 5500+ System is built on a legacy of cutting-edge engineering innovation. The quality and care are evident in the design of this mass spectrometer. The ion path contains multiple unique technological advances that will enable your laboratory to produce superior results.

Whether you are focusing on pharmaceutical drug discovery workflows, clinical research, food and beverage testing, complex environmental analysis, academic studies, or searching for answers from crucial forensic samples, the 5500+ system is equipped to handle the challenge.

The modular framework of the SCIEX 5500+ System enables additional component upgrades to enhance your data. The instrument is compatible with SelexION® differential mobility separation which delivers exceptional selectivity of isobaric compounds. If your workflow demands low flow rates, the OptiFlow® Turbo V™ Ion Source is the ideal technology to achieve your goals. Optimized for microflow chromatography, the OptiFlow ion source can further increase sensitivity, improve selectivity and reduce the consumption of solvents and other consumables.

The SCIEX 5500+ system – QTRAP extends the capabilities of traditional triple quadrupole LC‑MS/MS by integrating linear ion trap functionality into the mass analyzer and allowing laboratories to perform high‑sensitivity quantitation and confident confirmation within a single platform.

Rather than choosing between quantitative performance and qualitative insight, SCIEX 5500+ system - QTRAP supports both, enabling laboratories to streamline workflows while maintaining confidence in compound identification, even in complex matrices. Among other attributes, the system allows you to:

Address quantitation challenges in complex matrices
Improve throughput by reducing repeat analysis
Support screening and characterization of unknowns
Extend workflows beyond targeted quantitation
HIGHLIGHTS:
Turbo V ion source
Simplistic source architecture and orthogonal spray design provides uniform temperature distribution and delivers extraordinary robustness and ruggedness across a wide range of compound types

OptiFlow Turbo V ion source
Switch to the optional OptiFlow Turbo V ion source for low-flow analyses. It is robust and simple to operate, and supports a wide flow rate range of 1 - 2000 µL/min.

HED detector and high capacity CEM
Increased productivity with fast polarity switching of 5 msec enabling up to 6 orders of magnitude of linear dynamic range

Scout triggered MRM (stMRM)
Eliminate the need to maintain precise retention times for all analytes in MRM acquisition methods

Mass range
A range of 5 to 1250 m/z encompasses many compound classes, enabling your organization to test for more analytes and explore your laboratory’s potential

Patented Dual QJet ion guide
Improved ion sampling, collisional focusing and ion transmission for outstanding sensitivity

Patented Curtain Gas interface
Proven protection against mass contamination providing consistent data quality over long runs with minimal downtime

MRM acquisition rate
With an acquisition rate of 500 MRMs per secound, even without using Scheduled MRM, the SCIEX 5500+ system series can analyze an extensive suite of compounds

The Triple Quad 6500 Systems with revolutionary, multi-component IonDrive Technology merges highly-evolved sensitivity with renowned performance. Adopting an intelligent approach to increasing the limits of quantitation, the IonDrive Technology introduces a series of advancements that increases the quantity of ions produced while enhancing the way ions are transmitted and detected.

Key Overview
• Core Technology: Features multi-component IonDrive Technology (IonDrive Turbo V source, IonDrive QJet guide, and IonDrive High Energy Detector) to boost ion production, transmission, and detection.
• Configurations: Available as a Triple Quad (pure quantitative MS/MS) or QTRAP (hybrid triple quadrupole/linear ion trap for combined quantitative and qualitative workflows).

Main Technical Specifications

• Mass Range: 5–2,000 Da (Triple Quad) or 50–2,000 Da for the linear ion trap on QTRAP models.
• Linear Dynamic Range: Up to 6 orders of magnitude.
• Polarity Switching: 5 ms (in MRM and Scheduled MRM modes).
• Scan Speed: Up to 12,000 Da/sec.
• Optional Add-ons: Compatible with SelexION+ Differential Mobility Spectrometry (DMS) for separating isobaric species and lowering background noise.

High-throughput mass spec

This system is the fastest and most sensitive QTRAP. It provides the best LOQs to enable the detection and quantification of the broadest scope of chemical compounds in the most challenging matrices. Improved polarity switching and MRM³ speeds allow faster chromatography and better throughput. The built-in QTRAP functionality enables quantitative MRMs and qualitative QTRAP scans in the same injection to maximize throughput.

The system is ideal for laboratories performing demanding applications requiring ultimate sensitivity for ultra-low-level quantitation of small and large molecules.

Experience extraordinary sensitivity gains from the SCIEX 7500 system. Start detecting the previously undetectable, and quantify at lower levels with impressive precision.

Expand your laboratory capabilities to test dirty and complex samples. The new D Jet ion guide will allow you to characterize analytes that were once masked by matrices.

Quantify more trace analytes at lower levels. Simplify sample prep, and inject less sample using the OptiFlow Pro ion source. And boost the transition of crucial ions into the system with the integrated E Lens probe.

Features:

D Jet ion guide

The D Jet ion guide concentrates samples and removes gas molecules and neutral ions.

QTRAP system

Enhanced product ion scans enable improved confidence, while MRM³ workflows push quantification levels through matrix interferences.

Detection

Attain lower levels of quantification while focusing on the crucial ions you need for your workflow

Ionization source

The OptiFlow Pro ion source introduces a new modularity feature and incorporates the reliability and efficiency of the legendary Turbo V ion source.

E Lens probe

With the E Lens probe, the Turbo V ion source geometry is enhanced in the new OptiFlow Pro ion source

The Agilent 6470B triple Quadrupole LC/MS delivers superior reliability, sensitivity, and robustness for targeted trace-level analysis. Designed with robustness, versatility, and throughput in mind, it contains Agilent's signature octopole ion guide, hyperbolic quadrupoles, curved and tapered hexapole collision cell, and advanced detector geometry. Built with VacShield to reduce instrument downtime providing faster maintenance without breaking vacuum. The end result is a rugged and versatile instrument suitable for high-throughput targeted screening or trace-level quantitative research applications.
Key features:
• VacShield VacShield dramatically reduces maintenance by 92% for this instrument, by allowing the user to easily remove the Ion Injector without venting the MS system. This reduces the cleaning cycle to approximately 30 minutes compared to at least 6 hours for maintenance by venting and disassembly. This means the 6470B can be operational much faster than the previous system.
• Ultra-robust ion optics rail Greater reliability and system uptime are key components to achieving greater lab productivity and “getting the most” out of an instrument purchase. The 6470B utilizes the same high-powered ion optics rail as the 6495C, providing the same sensitivity and mass. In addition to workhorse capabilities, this also enables users to venture into more research-oriented applications such as peptides, polymers, and oligonucleotides, or focus on different types or aspects of their analysis.
• High-speed electronics control Updated electronics provides improved speed and performance to match the most strenuous methods needed to meet customer demands. Customers running a single chromatographic method for multiresidue compound screening of 200+ compounds (Pesticides, Veterinary Drugs, Toxicology, Metabolites, Environmental contaminants, etc.) will see greater data fidelity, reproducibility, and sensitivity.

The 6495D triple quadrupole LC/MS system is an ultrahigh-performance system built for research and testing labs investigating large batches of samples. Equipped with the latest, innovative iFunnel technology, this LC/MS/MS achieves ppq-level detection limits for the most challenging analytes in heavy matrix, for example in omics, food, and environmental analysis, while providing high precision at sub-millisecond dwell times.

Ultimate mass spectrometry performance is complemented by built-in instrument intelligence designed for demanding, nonstop routine analysis. Features including AI-based SWARM tuning, VacShield, early maintenance feedback (EMF) dashboard, scheduled tune, and intelligent reflex ensure that the system stays productive longer at peak performance, giving you peace of mind. An optional oil free dry pump delivers unparalleled energy efficiency, further improving the bottom line of your business.

Features
*NEW: Edwards nXL200i enhanced oil free dry pump option, delivering over 50% savings in energy consumption and heat dissipation
*Fourth generation, innovative iFunnel technology captures more of the ESI plume during ionization, resulting in dramatic improvement of signal response and detection limit compared to non-iFunnel systems
*SWARM autotune obtains the absolute best system settings using a multifactorial optimization artificial intelligence algorithm
*Intelligent reflex workflows provide data-dependent sample reinjection protocols that focus on sample assurance or improvements in sample throughput
*VacShield enables quick and easy cleanup of matrix deposits without venting the system
*Scheduled tuning alleviates the burden of routine maintenance, so you know that the mass spectrometer is always at peak performance
*Early maintenance feedback provides an easy-to-read dashboard to help visualize LC/MS instrument health and anticipate upcoming maintenance events
*Application-focused tuning and workflows facilitate analysis and quantitation of lipids, metabolites, peptides, proteins (digested), PFAS, and pesticides
*Compound optimizer allows fast method development by enabling users to create methods or add new compounds to an existing method, with automatic tuning to develop an optimal MRM transition for each new compound
*Seamless method transfer between Agilent LC/MS instruments on MassHunter 12 or higher shortens method development time and eases the burden of moving methods from system to system

The Agilent 6890 is a leading GC system with state of the art dynamic temperature programming, EPC pneumatics and flow controls.

The 6890 comes equipped with a split-splitless injection system that supports a wide variety of sample introduction techniques including thermal desorption, on-column injection, solid-phase micro-extraction (SPME), direct headspace injection, and solvent-based injections.

Standard equipment includes a flame ionization detector (FID) ideal for running serial parrafins for retention index determinations.

The Agilent’s well-documented reliability and ability to deliver extremely stable retention times make GCO and dilution analysis a robust sensory/analytical method.

The HP Agilent 6890 (G1530A) Plus Gas Chromatograph with Dual Split/Splitless Inlet is designed for an array of applications including: hydrocarbon processing, food safety, pesticide determination, chemical analysis, biodiesel, drug screening, toxicology, environmental and law enforcement.

The HP 6890 Series gas chromatograph system delivers unprecedented levels of performance, convenience, productivity, and eases regulatory compliance. The HP 6890 series GC features electronic pneumatics control of all gas pressures and flows. Onboard sensors automatically compensate for ambient temperature changes and barometric pressure differences to routinely achieve more accurate and reproducible results.

Agilent 7890

• Retention Time Locking (RTL) maintains exact retention times from injection to injection, column to column, instrument to instrument, and lab to lab
• Capillary Flow Technology (CFT) provides unique instrument capabilities, such as multi-dimension gas chromatography (GC-GC/Deans Switch), comprehensive two-dimension gas chromatography (GCxGC) with flow modulation, and backflush at the beginning, middle, or end of the analytical column
• Single filament TCD that does not require a separate reference gas, does not require manual potentiometer adjustment, and provides a stable baseline with a minimal amount of signal drift
• Auto-ranging FID provides the ability to detect and quantitate from parts per billion (ppb) to parts per thousand in a single injection
• Integrated SCD/NCD (sulfur or nitrogen chemiluminescence detector) provides low ppb detection, equi-molar response, and quantitation for sulfur or nitrogen contaminants without quenching from matrix
• Carrier Gas Options: Helium Conservation Module, Hydrogen Sensors and Alternate Carrier Gas Solutions dramatically reduce the amount of helium used to offer flexibility in your laboratory
• Large Valve Oven (LVO) allows for the combination of multiple methods and simplified maintenance
• Multimode inlet (MMI) serves as a programmable temperature vaporizing injector with flexible capabilities
• Agilent Inert Flow Path provides increased sensitivity for active compounds, from injection to detection
• Low Thermal Mass (LTM) modules, up to 4 installed and operating, increase sample throughput with rapid column heating and cooling