Experts in Dependable, Real-Time PCR Analyzers

The m2000 RealTime System incorporates a unique combination of leading science and enabling solutions.

Leading Science
*RealTime assays provide proven accuracy, for reliable and accurate subtype and genotype detection
*Proprietary maxRatio data analysis eliminates subjective result review for improved confidence in patient results
*Advanced automation that extends from primary tubes to patient results helps optimize efficiency and walk-away time
*Innovative IT enhancements, which centralize all molecular data into one location, keeps you at the forefront of automation

Enabling Solutions
*A comprehensive family of mSystem products enable flexible throughput options and allows you to improve turnaround time
*Consolidation capabilities, including IVD assays, Laboratory Defined Applications (LDAs) and open-mode extraction protocols helps you meet your lab's specific needs
*Leading-edge technologies provide cost-effective control strategies and improve ease of use
*Proven platform reliability gives you added confidence in patient results

The 16-capillary 3130 XL Genetic Analyzer gives you all the benefits of the Applied Biosystems suite of fluorescence-based capillary electrophoresis (CE) systems. Both systems offer industry-leading performance, plus sophisticated automation capabilities that make the most of your time and increase your lab’s productivity. The versatile, next-generation 3130 Series Systems deliver higher data quality, faster turnaround times, improved automation, and greater reliability across the complete range of sequencing, resequencing (mutational profiling),
and fragment analysis applications.

The 3500 Genetic Analyzer is an 8-capillary sequencing instrument specifically designed to support the demanding performance needs of validated and process controlled environments, while retaining the unsurpassed application versatility that life science researchers expect.
Features include:

• An 8 capillary system that can easily be upgraded to a 24-capillary system when you’re ready.
• Single-line, 505 nm, solid-state, long-life laser that utilizes a standard power supply and requires no heat-removal ducting
• Powerful, integrated data collection and primary analysis software provides real-time assessment of data quality
• Radio frequency identification (RFID) technology tracks key consumables data and records administrative information
• Advanced multiplexing capabilities for DNA fragment analysis with up to six unique dyes
• Unrivaled application flexibility—one array and one polymer are used for most applications.
• Simple setup, operation and maintenance

The 24-capillary 3500xL Genetic Analyzer sets the standard in capillary electrophoresis. The 3500-series instruments are the first genetic analyzers designed with a specific feature set and workflow for the Human Identification application.

• Increased Consistency – Reduced signal variation with factory standardization and optional in-lane normalization
• Real-Time Data Quality Assessment – On instrument data evaluation features provide rapid identification and re-injection of samples requiring additional processing
• Improved Thermal Control – Smaller oven design and improved door seal for more consistent data migration
• HID Specific Workflow – Pre-configured for Applied Biosystems® amplification kits to simplify run setup and software navigation
• Effortless Consumable Installation – Convenient one-time use consumable packaging
• Consumable Tracking with RFID Technology – On-instrument, real-time monitoring of consumable consumption and expiration
• Enhanced Throughput – Faster data generation with 8 or 24 capillary arrays and shorter run times
• Improved Polymer Pump Design – Reduced waste and fewer bubbles for better data quality
• Simplified Instrument Installation & Operation – New solid-state laser eliminates need for high voltage wiring and external venting
• Streamlined Instrument Maintenance – HID specific performance check and maintenance scheduling tools
• Data Chain of Custody – Controlled access and tracking through Security, Audit and eSig features

The 48-capillary 3730 DNA Analyzer is the Gold Standard in medium-to-high throughput genetic analysis. Use the 3730 DNA Analyzer for DNA fragment analysis applications such as microsatellites, AFLP, SNP analysis, mutation detection and traditional DNA sequencing. Get the highest quality data at a low cost per sample. This is upgradeable to 96 capillaries.

• Higher optical sensitivity and advanced polymers enable you to obtain higher-quality data at a lower cost.
• Multiple automation features decrease costly human errors.
• Optimized polymers increase your productivity without compromising your results.
• Perform a wide variety of sequencing and fragment analysis applications including resequencing, microsatellite analysis, AFLP, LOH, SSCP, SNP screening and SNP validation.

The 96-capillary 3730xl DNA Analyzer is the Gold Standard for high throughput genetic analysis. Use this for DNA fragment analysis applications such as microsatellites, AFLP, SNP analysis, mutation detection and traditional DNA sequencing. Get the highest quality data at a low cost per sample.
• Higher optical sensitivity and advanced polymers enable you to obtain higher-quality sequencing data for less.
• Multiple automation features decrease costly human errors.
• Optimized polymers increase your productivity without compromising your results.
• Perform a wide variety of sequencing and fragment analysis applications including resequencing, microsatellite analysis, AFLP, LOH, SSCP, SNP screening and SNP validation.

Large-Scale DNA Analysis on a Small-Scale Budget
By combining advances in automation with innovative optics and proprietary reagents to increase throughput, yield high-quality data, and minimize reagent consumption, the 3730xl Analyzer provides your laboratory and production facility with faster, better, cheaper analysis.

Streamline Your Workflow
The 3730xl DNA Analyzer system is engineered for highly reliable, unattended operation of up to 48 hours (applies to modules with run times longer than 30 minutes). To minimize the need for operator intervention and decrease the risk of human error, automation features include an integrated plate stacker, internal bar code reader, and onboard polymer delivery system.

Increase Productivity
The high signal-to-noise ratio ensures you get high-quality data – even when you use low-concentration samples and reagents. Labor-saving automation features minimize hands-on time and enable you to analyze more data more efficiently.

Get the Highest-Quality Sequencing and Genotyping Data
The enhanced optical design provides a higher signal-to-noise ratio and a more uniform signal profile across the array. This design, combined with our new, advanced polymer, enables the longest read lengths of any available system, and provides enhanced color balance for streamlined genotyping sample handling. In addition, exceptional sensitivity enables higher success rates across a wide range of sample template types and concentrations.

One Instrument, Multiple Applications
With the 3730xl DNA Analyzer, you get the highest-quality data from a wide array of applications. In addition to being ideal for high-throughput sequencing, the analyzer's optimized application assays, instrument, and analysis software also provide a complete solution for genotyping and resequencing.

Integrated Data Analysis Tools Reduce Time-to-Results
The 3730xl DNA Analyzer software suite allows you to generate more meaningful data with less work. This system's labor-saving software suite includes:
• Data Collection (supplied with the instrument) – Manages your instrument setup, controls instrument operations, allows real-time data visualization, and performs diagnostics.
• Sequencing Analysis Software – Designed to base-call; assign quality values; trim, display, edit and print DNA sequencing data using the KB basecaller
• Seqscape® – Provides everything you need to perform resequencing applications such as VariantSEQr™ Resequencing System
• GeneMapper® – Enables configurable, automated allele calling; a plus for high-throughput genotyping and includes tools for SNPlex™ data analysis

New features include:
• Auto-analysis with GeneMapper® and SeqScape®
• Flexibility to use any choice in dye set option
• Tools to assist with regulatory and compliance requirements (In the United States, this assists with FDA 21CFR part 11).
• Additional optimized run modules covering more applications
• Support for fragment analysis applications on the 96-capillary array

• The 7500 Real-Time PCR System is a versatile, leading-edge platform providing enhanced performance capabilities and an upgrade path to high-speed thermal cycling

• Five-color detection system provides the flexibility to perform a variety of applications including gene expression analysis, SNP genotyping and plus/minus assays that utilize internal positive controls

• Advanced optical configuration supports a broader range of fluorophores, including FAM™/SYBR® Green I, VIC®/JOE™, NED™/ TAMRA™/Cy3™, ROX™/Texas Red® , and Cy5™ dyes; variable excitation capability allows greater sensitivity for longer wavelength (red) dyes

• Powerful, flexible software includes new plate setup wizards to guide you through experimental setup, while automated analysis tools such as RQ Study (Relative Quantitation) gene expression analysis software allow the simultaneous analysis and visualization of up to ten 96-well plates of data

The 7500 Fast Real-Time PCR System enables standard 96-well format high speed thermal cycling, significantly reducing your run time for quantitative real-time PCR applications, delivering results in about 35 minutes

• The 7500 Real-Time PCR System is a versatile, leading-edge platform providing enhanced performance capabilities and an upgrade path to high-speed thermal cycling

• Five-color detection system provides the flexibility to perform a variety of applications including gene expression analysis, SNP genotyping and plus/minus assays that utilize internal positive controls

• Advanced optical configuration supports a broader range of fluorophores, including FAM™/SYBR® Green I, VIC®/JOE™, NED™/ TAMRA™/Cy3™, ROX™/Texas Red® , and Cy5™ dyes; variable excitation capability allows greater sensitivity for longer wavelength (red) dyes

• Powerful, flexible software includes new plate setup wizards to guide you through experimental setup, while automated analysis tools such as RQ Study (Relative Quantitation) gene expression analysis software allow the simultaneous analysis and visualization of up to ten 96-well plates of data

The Applied Biosystems® 7500 Fast Dx Real-Time PCR Instrument with SDS Software is a real-time nucleic acid amplification and five-color fluorescence detection system available for in vitro diagnostic use. The 7500 Fast Dx Real-Time PCR Instrument delivers the performance required for high-quality results in a 96-well format.

• 96-well format eases plate setup if automation is not available
• Accommodates tube strips, which can be capped immediately after pipetting each sample
• Fast mode completes runs in less than forty minutes
• Optional standard mode facilitates use of standard length real-time PCR assays without changing thermal cycling parameters
• 5-color variable excitation enables multiplex assays

<b>Convenient 96-well Format</b>
The 7500 Fast Dx Real-Time PCR Instrument minimizes the effort required to perform sample setup while also allowing the use of tube strips.

<b>Intuitive Software to Run Pre-optimized Protocols</b>
The 7500 Fast Dx instrument's Sequence Detection Software Security, Auditing, and E-Signature module offers the flexibility to develop assays and also run pre-optimized protocols for users operating in a secure environment.

The 7900HT Fast Real-Time PCR System is a real-time quantitative PCR system that combines 96- and 384-well plate compatibility and the TaqMan® Low Density Array with fully automated robotic loading-and now also offers optional Fast real-time PCR capability.

• Fast PCR option reduces run time to about 35 minutes in a standard 96-well format, or about 55 minutes in a 384-well plate
• Continuous wavelength detection from 500-660 nm allows the use of multiple fluorophores in a single reaction
• Measure gene expression levels, detect and quantitate pathogens, perform allelic discrimination (SNP genotyping) assays as well as score the presence of gene sequences
• 96- or 384-well plate compatibility (including the TaqMan® Low Density Array)
• Optional Enterprise edition software provides data analysis tools that support 21 CFR Part 11 guidelines providing data integrity and security
• Hands-free plate-loading and unloading provides true walkaway automation allowing you to increase your lab's productivity
• Proven assay development guidelines save time and money

High Throughput
The 7900HT System is a high-throughput real-time PCR system that detects and quantitates nucleic acid sequences. An optional Automation Accessory (not included) combined with 384-well plate capability make the 7900HT system ideally suited to meet the high-throughput requirements of today's drug discovery process. Key applications include gene expression quantitation and the detection of single nucleotide polymorphisms (SNPs) using the fluorogenic 5' nuclease assay.

Flexibility
The 7900HT system is a versatile research tool that can accommodate any real-time PCR need. User-interchangeable thermal cycling block formats let you select the format that’s right for your project, using industry-standard 96- and 384-well formats, as well as a novel 384-well TaqMan® Low Density Array and a new Fast 96-well block that reduces run times from 2 hours to about 30 minutes. An easy automation upgrade path lets you add features to meet throughput demands. A Fast PCR option reduces run times from 2 hours to about 30 minutes.

Powerful Software
Using two automation software tools, Plate Utility and Automation Controller, most of the gene expression and SNP genotyping workflow is fully automated for high-throughput applications and requires minimal user intervention. You can now process 5,000 x 384 well plates (384 markers), which equates to 1.92 million genotypes. Using Relative Quantification (RQ) Manager, you can also process 200 x 384-well plates (96 detectors with quadruplicate data points⁄multiplexed endogenous control), which equates to 153,600 data points. Fully integrated into one complete Enterprise system, SNP Manager and RQ Manager eliminate data analysis bottlenecks in high-throughput SNP and gene expression research by allowing significantly more plates to be analyzed simultaneously. This reduces hands-on analysis time and simplifies the data analysis workflow.

The GeneXpert System is available in a one, two, four, or 16-module configuration. All have our proven GeneXpert module at their analytic heart, and use the same patented cartridge technology for every Xpert® test.GeneXpert IGeneXpert IIGeneXpert IVGeneXpert XVI

With the GeneXpert System, labs no longer need rows of equipment and extensively trained staff to deliver molecular results. No matter which GeneXpertSystem you choose, Cepheid’s technology makes on-demand molecular testing available to everyone with unprecedented speed and ease-of-use.

The cornerstone of the GeneXpert testing process is Cepheid’s patented, self-contained, single use cartridge. Sample extraction, amplification and detection are all carried out within this self-contained “laboratory in a cartridge”.

The GeneXpert® System fully integrates and automates sample extraction, amplification, and detection — all in one cartridge. On-demand.Just load a biological sample and the system does the rest.

The simplicity of the GeneXpert® System is often compared to a chemistry or hematology analyzer. Simply load the cartridge and the system does the rest. And all of Cepheid’s GeneXpert Systems offer complete interfacing compatibility with your data management system, enabling your clinical staff to take full advantage of the speed and accuracy of molecular diagnostics.

For outstanding performance in real-time PCR
*Outstanding thermal and optical performance due to rotary format
*An unmatched optical range spanning UV to infrared wavelengths
*State-of-the art analyses supported by user-friendly software
*Low maintenance and maximum convenience due to robust design
*High performance in multiple applications with QIAGEN assays
QIAGEN's real-time PCR cycler, the Rotor-Gene Q, combines multiple optimized design features to provide the outstanding performance and reliable results that your research demands. Together with optimized QIAGEN kits for real-time PCR, the Rotor-Gene Q enables streamlined analysis for a wide range of applications. Q-Rex Software is operating and analysis software for life science qPCR applications. A choice of plug-ins lets you add new functionality without affecting established workflows.

The cobas® 4800 System fully automates sample preparation with real-time polymerase chain reaction (PCR) technology for amplification and detection.

The cobas® 4800 System offers high lab workflow efficiency, a consolidated assay menu, and the confident results you expect to consistently deliver high quality service and support to your clinicians and patients.

Workflow efficiency
The cobas® 4800 System brings flexible sample loading to your fingertips. Handling multiple types of primary and secondary vials in the same run, laboratories can reduce manual effort, improve efficiency and reduce the risk of error, to more efficiently manage daily workflow.